Heparin binding protein (HBP) is an infection indicator that has been widely discussed by experts and scholars in recent years, and its clinical significance in the diagnosis, treatment and diagnosis of sepsis has been confirmed in guidelines for The Treatment of Sepsis 2014 and Expert Consensus for early Prevention and Diagnosis of Sepsis 2020.

In May this year, the expert consensus pointed out that HBP, as an acute time phase protein, is an effective biomarker for the assessment of disease severity in patients with sepsis, and is more important in the early diagnosis and efficacy monitoring of patients with septic shock.

In our previous article, we specifically discussed the "Four Inflammatory Factors: IL-6, PCT, CRP and SAA Market Status and Opportunities review!" Today I'm going to talk to you about HBP, an upstart in the field of infection, about the current state of the industry and its future prospects.

HBP also calls the azure kill or CAP73, bacteria structure may induce HBP in neutrophils release, fastest response to pathogens, from hangzhou X company introduced into China in 2014, the company invested heavily in HBP on research and development production and sales, the early made a very good market response, it should be said that in terms of the index itself has made the major inspection field experts, only learn the sensitivity and specificity in the diagnosis of sepsis were higher than the PCT (pictured), has also been the recognition of clinical doctors.

What about the market for HBP? Small make up to now can manufacturer supply HBP has 5 two separate HBP card and three card is PCT combined HBP, the small make up to two separate HBP and a patent dispute, between the inside of the curved behing small make up is not tired, anyway China patent lawsuits foreign companies to win need to fairly solid evidence.

Of course, this is also to protect the healthy and vigorous development of IVD industry in China, among which PCT combined with HBP is the most intriguing. Manufacturers combine these two indicators to meet clinical needs and leave a good space for agents.

As upgrade of PCT, HBP has incomparable advantage, he is the only one can be predicted in advance of sepsis inflammation index, predicted two word solved the difficulty and pain points of clinical doctors, you know not the hardest part about sepsis treatment but how to identify sepsis, many patients with sepsis are slow hospital can't timely recognition or rescue delayed treatment, then predict the characteristics are valuable.

For patients with severe sepsis, HBP can predict sepsis 10.5 hours in advance, which buys precious rescue time for patients. It should be said that he is an upstart in the field of infection, with clinical value higher than PCT and market value equivalent to roche's PCT 10 years ago. If Roche asked you to represent his PCT 10 years ago, would you consider it?

What are the prospects for HBP? Is the current domestic already has 14 provinces have HBP charge code, price between 240-340, according to the small make up to understand the indicators used in coastal areas of jiangsu and zhejiang is quite extensive, led by zhejiang hospital dean yan X national multicenter study is under way, including mainly around the sepsis, bacterial meningitis, pyelonephritis HBP application to expand.

That is to say, this index has a very broad prospect in ICU, emergency department, respiratory department, tumor department, kidney department and other clinical departments. Of course, the market belongs to those who dare to eat crab, and one or two of these five enterprises will emerge as new forces and dominate in the new field of inflammatory indicators. As experienced IVD practitioners, are you ready?